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Disorders of the Skeletal Muscle

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

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Related Experiment Video

Updated: May 18, 2026

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

Published on: March 1, 2024

Tendinopathy in sport.

Paul W Ackermann¹, Per Renström

¹Section of Orthopedics and Sports Medicine, Department of Molecular Medicine and Surgery, Stockholm Sports Trauma Research Center, Karolinska Institutet, Stockholm, Sweden.

|September 28, 2012

Summary

Tendinopathy, a common disorder, is linked to genetic and metabolic factors. Eccentric exercise is the primary treatment, with shockwave therapy showing promise, while injections offer limited long-term benefits.

Area of Science:

Orthopedics
Sports Medicine
Regenerative Medicine

Background:

Tendinopathy prevalence is rising, impacting sports and occupational health.
Limited high-quality data exists on tendinopathy causes and treatments.

Purpose of the Study:

To review the epidemiology, etiology, and current treatment strategies for tendinopathy.
To emphasize evidence-based, patient-oriented research.

Main Methods:

Conducted a MEDLINE search for tendinopathy (1980-2011).
Focused on epidemiology, etiology, and Level 1 evidence for treatments.

Main Results:

Risk factors include repetitive stress, genetic variants, and metabolic disorders.
Tendinosis involves fibrotic changes and nerve ingrowth, contributing to pain.

Keywords:

pain tendinopathy tendinosis tendon

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Last Updated: May 18, 2026

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

Published on: March 1, 2024

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Engineering Tendon Assembloids to Probe Cellular Crosstalk in Disease and Repair

Published on: March 22, 2024

Eccentric exercise is the cornerstone of treatment; shockwave therapy may enhance outcomes.

Injections offer short-term relief but lack proven long-term efficacy; surgery is less indicated.

Mini-invasive procedures show promise but require further validation.

Conclusions:

Emerging targeted therapies require validation through multicenter trials.
Exercise and minimally invasive treatments show potential but need confirmation.