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Pulsatile pressure can prevent rapid baroreflex resetting.

D Mendelowitz¹, A M Scher

¹Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle 98195.

The American Journal of Physiology

|January 1, 1990

Summary

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Pulsatile pressure maintains baroreflex responses, preventing rapid resetting unlike static pressure. This study shows minimal baroreflex resetting occurs with pulsatile pressure, crucial for cardiovascular regulation.

Area of Science:

Cardiovascular Physiology
Autonomic Nervous System Regulation

Background:

Baroreflex responses typically decay or reset with sustained increases in static sinus pressure.
Previous findings suggested pulsatile pressure might preserve baroreflex function.

Purpose of the Study:

To conclusively determine if pulsatile pressure prevents rapid baroreflex resetting.
To quantify baroreflex resetting under static versus pulsatile pressure conditions.

Main Methods:

Isolated rabbit sinus preparation subjected to static or pulsatile pressures.
Baroreflex curves determined by stepwise changes in sinus pressure.
Analysis of threshold, midpoint, and saturation pressures and response decay.

Main Results:

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Static pressure conditioning caused significant shifts (25-39%) in baroreflex thresholds, midpoints, and saturation points.
Pulsatile pressure conditioning resulted in no significant shifts in these baroreflex parameters.
Baroreflex responses decayed with static pressure but were maintained with pulsatile pressure.

Conclusions:

The baroreflex demonstrates rapid resetting in response to static pressure changes.
Pulsatile pressure significantly minimizes or prevents baroreflex resetting.
These findings highlight the importance of pressure waveform in maintaining baroreflex sensitivity.