Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sense of Coherence in patients with stable schizophrenia: multidimensional determinants from a cross-sectional study of 438 inpatients in Guangzhou, China.

Frontiers in psychiatry·2026

Same author

Construction of China's climate civil public interest litigation system-from the perspective of public health protection and medical assistance.

Frontiers in public health·2026

Same author

Immune cell-mediated effects of plasma lipids on heart failure: A two-step, two-sample Mendelian randomization study.

Medicine·2026

Same author

A programmable and self-adaptive ultrasonic wireless implant for personalized chronic pain management.

Nature electronics·2026

Same author

Chicken Infectious Anemia Virus Markedly Enhances the Pathogenicity of Infectious Bronchitis Virus-Infected Chickens.

Transboundary and emerging diseases·2026

Same author

Autologous osteoperiosteal transplantation from the iliac crest for the treatment of large osteochondral lesions of the talus.

International orthopaedics·2026

Search research articles

Related Experiment Video

Updated: May 18, 2026

The Fabrication and Operation of a Continuous Flow, Micro-Electroporation System with Permeabilization Detection

The Fabrication and Operation of a Continuous Flow, Micro-Electroporation System with Permeabilization Detection

Published on: January 7, 2022

[The sub-microsecond pulser applied for electroporation effect].

Yafang Tan¹, Hongchun Yang, Jianxing Wu

¹Physical Electronics College, University of Electronics Science and Technology of China, Chengdu 610054, China.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi

|September 29, 2012

Summary

This summary is machine-generated.

This study presents a new generator for sub-microsecond electrical pulses, crucial for studying tumor cell electroporation. The device offers adjustable parameters for precise experimental control in cancer research.

More Related Videos

Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery

Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery

Published on: August 7, 2014

Monitoring Electroporation-Induced Changes in Action Potential Generation in Genetically Engineered Tet-On Spiking HEK cells

Monitoring Electroporation-Induced Changes in Action Potential Generation in Genetically Engineered Tet-On Spiking HEK cells

Published on: September 6, 2024

Related Experiment Videos

Last Updated: May 18, 2026

The Fabrication and Operation of a Continuous Flow, Micro-Electroporation System with Permeabilization Detection

The Fabrication and Operation of a Continuous Flow, Micro-Electroporation System with Permeabilization Detection

Published on: January 7, 2022

Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery

Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery

Published on: August 7, 2014

Monitoring Electroporation-Induced Changes in Action Potential Generation in Genetically Engineered Tet-On Spiking HEK cells

Monitoring Electroporation-Induced Changes in Action Potential Generation in Genetically Engineered Tet-On Spiking HEK cells

Published on: September 6, 2024

Area of Science:

Biophysics
Electrical Engineering
Oncology

Context:

Electroporation is a method used to enhance drug delivery or gene transfection in cells.
Precise control over electrical pulse parameters is essential for effective and targeted electroporation.
Tumor cell electroporation requires specialized equipment capable of delivering specific waveforms.

Purpose:

To develop and present a novel sub-microsecond pulse generator.
To enable precise control over pulse amplitude, duration, and frequency for electroporation studies.
To provide a versatile tool for investigating electroporation effects on tumor cells.

Summary:

A generator producing sub-microsecond electrical pulses was developed using an RC discharge curve and IGBT modules.
The system allows for adjustable pulse parameters: 0.5-3.5kV amplitude, 300-800 ns duration, and 1-400Hz repetition rate.
Experimental validation confirms the generator's capability to produce the desired adjustable pulse waveforms.

Impact:

Facilitates advanced research into tumor cell electroporation mechanisms.
Offers a reliable platform for developing novel cancer treatment strategies utilizing electroporation.
Contributes to the field of biomedical engineering with a specialized pulse generation system.