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Related Experiment Video

Updated: May 18, 2026

In Vitro Growth of Mouse Preantral Follicles Under Simulated Microgravity
10:48

In Vitro Growth of Mouse Preantral Follicles Under Simulated Microgravity

Published on: December 17, 2017

[Tail-suspended model simulating mouse oocytes maturation inhibited with microgravity].

Changli Wu1, Li Li, Hengxi Wei

  • 1College of Animal Science, South China Agriculture University, Guangzhou 510642, China.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi
|September 29, 2012
PubMed
Summary
This summary is machine-generated.

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Simulated microgravity negatively impacts mouse oocyte maturation. The tail-suspension model effectively demonstrates these adverse effects on female reproductive processes.

Area of Science:

  • Reproductive biology
  • Space biology
  • Cell biology

Context:

  • Investigating the impact of microgravity on reproductive health is crucial for long-duration space missions.
  • Understanding cellular and molecular changes in oocytes under simulated microgravity is essential for assessing fertility risks.
  • Current models for simulating microgravity need validation for their efficacy in studying reproductive processes.

Purpose:

  • To evaluate the effects of simulated microgravity on mouse oocyte maturation.
  • To compare the efficacy of a rotating wall vessel bioreactor and a tail-suspension model in simulating microgravity's effects on oocytes.
  • To determine the suitability of the tail-suspension model for studying female reproductive processes under microgravity.

Summary:

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Mouse Oocyte Microinjection, Maturation and Ploidy Assessment

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Related Experiment Videos

Last Updated: May 18, 2026

In Vitro Growth of Mouse Preantral Follicles Under Simulated Microgravity
10:48

In Vitro Growth of Mouse Preantral Follicles Under Simulated Microgravity

Published on: December 17, 2017

Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes
10:09

Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes

Published on: September 13, 2022

Mouse Oocyte Microinjection, Maturation and Ploidy Assessment
07:03

Mouse Oocyte Microinjection, Maturation and Ploidy Assessment

Published on: July 23, 2011

  • Mouse oocytes cultured under simulated microgravity using a rotating wall vessel bioreactor showed a maturation rate of 8.93% compared to 72.33% in 1g gravity, with no significant difference from the control group.
  • Simulated microgravity via the tail-suspension model significantly inhibited mouse oocyte maturation (14.54%) and increased oocyte abnormality rates compared to the control group.
  • The tail-suspension model proved to be an effective and ideal model for investigating the effects of simulated microgravity on female mouse reproductive processes.

    • Impact:

    • The tail-suspension model provides a viable and effective method for studying the impact of microgravity on female reproductive health.
    • Findings highlight potential risks to oocyte quality and maturation in space environments, informing future research and countermeasures.
    • This study contributes to the broader understanding of spaceflight's effects on mammalian reproduction.