Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Blood-brain Barrier00:49

The Blood-brain Barrier

52.1K
Overview
52.1K
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

1.4K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.4K
Physiological Barriers01:25

Physiological Barriers

5.0K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
5.0K
Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport01:23

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

1.5K
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
1.5K
Drug Delivery: Overview01:16

Drug Delivery: Overview

693
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
693

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Diagnostic value of parameters of glucose metabolism as screening tests for insulinoma].

Zhonghua yi xue za zhi·2010
Same author

Cooperative binding of MgATP and MgADP in the trimeric P(II) protein GlnK2 from Archaeoglobus fulgidus.

Journal of molecular biology·2010
Same author

Autophagy plays an important role in sunitinib-mediated cell death in H9c2 cardiac muscle cells.

Toxicology and applied pharmacology·2010
Same author

Design and synthesis of novel benzimidazole derivatives as inhibitors of hepatitis B virus.

Bioorganic & medicinal chemistry·2010
Same author

Evaluation of genetic susceptibility loci for obesity in Chinese women.

American journal of epidemiology·2010
Same author

Up-regulation of death receptor 4 and 5 by celastrol enhances the anti-cancer activity of TRAIL/Apo-2L.

Cancer letters·2010
Same journal

Comparative Phytochemical Characterization and Antibacterial Activity of Ethanol and Aqueous Extracts of Moringa peregrina and Moringa oleifera against Multidrug-Resistant Bacteria.

Current pharmaceutical biotechnology·2026
Same journal

Unveiling Aptamers for Targeted Tumour Therapies and Detection: Systematic Evolution of Ligands by Exponential Enrichment (SELEX) Technology in Oncology.

Current pharmaceutical biotechnology·2026
Same journal

Nanosuspensions-Based Dry Powder Inhalers for Pulmonary Delivery of Hydrophobic Natural Products: Formulation Strategies, Efficacy, and Challenges.

Current pharmaceutical biotechnology·2026
Same journal

Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Accelerate Diabetic Rat Wound Healing by Inhibiting Pyroptosis through the NLRP3/Caspase-1/GSDMD Pathway.

Current pharmaceutical biotechnology·2026
Same journal

Cyperotundone Regulates Polo-like Kinase 1-mediated Glycolysis to Inhibit the Proliferation of Breast Cancer Cells.

Current pharmaceutical biotechnology·2026
Same journal

Risk Factor Analysis and Nomogram for Predicting 28-day in-hospital Mortality in ICU Patients with Liver Necrosis.

Current pharmaceutical biotechnology·2026
See all related articles

Related Experiment Video

Updated: Jan 7, 2026

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery
08:22

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery

Published on: July 18, 2019

9.0K

Adsorptive-mediated brain delivery systems.

Wei Lu1

  • 1Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, The University of Rhode Island, 41 Lower College Road, Kingston, RI 02881, USA. weilu@uri.edu

Current Pharmaceutical Biotechnology
|September 29, 2012
PubMed
Summary
This summary is machine-generated.

This review discusses adsorptive-mediated transcytosis (AMT) for drug delivery across the blood-brain barrier (BBB). AMT utilizes cationic molecules to enhance the transport of therapeutics into the brain, overcoming BBB limitations.

More Related Videos

Implantation of Miniosmotic Pumps and Delivery of Tract Tracers to Study Brain Reorganization in Pathophysiological Conditions
10:32

Implantation of Miniosmotic Pumps and Delivery of Tract Tracers to Study Brain Reorganization in Pathophysiological Conditions

Published on: January 18, 2016

14.6K
Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice
08:25

Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice

Published on: July 16, 2014

11.2K

Related Experiment Videos

Last Updated: Jan 7, 2026

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery
08:22

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery

Published on: July 18, 2019

9.0K
Implantation of Miniosmotic Pumps and Delivery of Tract Tracers to Study Brain Reorganization in Pathophysiological Conditions
10:32

Implantation of Miniosmotic Pumps and Delivery of Tract Tracers to Study Brain Reorganization in Pathophysiological Conditions

Published on: January 18, 2016

14.6K
Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice
08:25

Heterotopic Mucosal Engrafting Procedure for Direct Drug Delivery to the Brain in Mice

Published on: July 16, 2014

11.2K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Biotechnology

Background:

  • The blood-brain barrier (BBB) restricts the central nervous system entry of many therapeutic agents.
  • Brain capillary endothelial cells and astrocytic end-feet form the BBB structure.
  • Current drug delivery methods face challenges in penetrating the BBB.

Purpose of the Study:

  • To review adsorptive-mediated transcytosis (AMT) as a strategy for enhanced drug delivery to the brain.
  • To explore the mechanisms of AMT across the BBB.
  • To discuss the potential of AMT for delivering various therapeutic substances.

Main Methods:

  • Focus on adsorptive-mediated transcytosis (AMT) mechanisms.
  • Utilizing cationic molecules (proteins, peptides) as targeting agents.
  • Conjugating therapeutic molecules or vectors with cationic targetors.

Main Results:

  • AMT is triggered by electrostatic interactions between cationic molecules and the BBB's anionic microdomains.
  • Cationic targetors facilitate the transport of large molecules and drug carriers across the BBB.
  • This approach enables brain parenchyma access for therapeutics.

Conclusions:

  • Adsorptive-mediated transcytosis offers a physiologically-based strategy for overcoming BBB drug delivery challenges.
  • AMT holds promise for enhancing the delivery of diverse therapeutic substances to the brain.
  • Further development of AMT systems can improve treatment of neurological disorders.