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Updated: May 18, 2026

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
Drug delivery systems from nose to brain
Ambikanandan Misra1, Gitanjali Kher
1Pharmacy Department, Faculty of Technology and Engineering, The M S University of Baroda, Kalabhavan, Vadodara, India. misraan@hotmail.com
Intranasal delivery offers a promising, non-invasive method to bypass the blood-brain barrier (BBB) for direct brain drug delivery. This review explores its potential, mechanisms, and systems for treating brain disorders.
Area of Science:
- Neuroscience
- Pharmacology
- Drug Delivery Systems
Background:
- Treating brain disorders is challenging due to obstacles in selective and effective drug delivery.
- The blood-brain barrier (BBB) significantly limits drug uptake into the brain after systemic administration.
Purpose of the Study:
- To review the potential of intranasal drug delivery for bypassing the BBB and targeting the brain.
- To discuss mechanisms, influencing factors, systems, techniques, and examples of intranasal brain drug transport for treating neurological disorders.
Main Methods:
- Literature review of scientific publications on intranasal drug delivery to the brain.
- Analysis of mechanisms, pathways, and factors affecting transnasal drug absorption.
- Evaluation of conventional and novel intranasal delivery systems, techniques, and devices.
Main Results:
- Intranasal delivery provides a direct route to the brain, bypassing the BBB.
- Various factors influence transnasal drug absorption, and different delivery systems can be employed.
- Feasible examples of intranasal drug transport for treating brain disorders are presented, including marketed and investigational drugs.
Conclusions:
- Intranasal delivery holds significant promise as a non-invasive strategy for brain drug delivery.
- Further research and development of intranasal systems are crucial for advancing the treatment of brain disorders.
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