Therapeutic gene products delivery by neuron stem cells
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Updated: Nov 25, 2025
Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
Published on: May 2, 2025
Jie Tan1, Yanna Meng, Shiang Huang
1Department of Stem Cell Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Abstract:
Malignant tumors remain virtually untreatable and inevitably lethal despite extensive surgical excision and adjuvant radio- and chemotherapy. Therefore, the development of more effective tumor-selective therapies is necessary. Stem/progenitor cells that self-renew, differentiate and display inherent tumor-tropic properties can be exploited for targeted delivery of therapeutic genes to invasive and metastatic tumors. In this review, we mainly introduce the application in Glioma, Breast cancer, Spinal cord injury, AD and so on. The promising field of stem cell research as it applies to regenerative medicine is still in infancy, but its potential appears limitless, and we are blessed to be involved in this exciting realm of research.
Insights
Stem cells offer a promising approach for targeted cancer therapy by delivering therapeutic genes directly to tumors. This review explores their application in treating gliomas, breast cancer, and other conditions.
Area of Science:
- Oncology
- Regenerative Medicine
- Stem Cell Biology
Background:
- Malignant tumors are difficult to treat with current methods like surgery, radiation, and chemotherapy.
- There is a critical need for novel, tumor-selective therapeutic strategies.
Purpose of the Study:
- To review the potential of stem/progenitor cells for targeted cancer therapy.
- To highlight applications in treating gliomas, breast cancer, and spinal cord injuries.
Main Methods:
- Review of current literature on stem cell applications in regenerative medicine and oncology.
- Discussion of stem cell properties like self-renewal, differentiation, and tumor-tropism.
Main Results:
- Stem/progenitor cells possess inherent tumor-tropic properties, enabling targeted delivery of therapeutic genes.
- Applications are being explored for various cancers and neurological conditions.
Conclusions:
- Stem cell-based therapies represent a promising frontier in regenerative medicine and cancer treatment.
- While still in early stages, stem cell research holds significant potential for future therapeutic advancements.
