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Updated: May 18, 2026

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry
08:07

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry

Published on: July 26, 2019

Genetic and epigenetic regulation of phosphoinositide 3-kinase isoforms

Chanse Fyffe1, Richard Buus, Marco Falasca

  • 1Inositide Signalling Group, Centre for Diabetes, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4Newark Street, London E1 2AT, UK.

Current Pharmaceutical Design
|September 29, 2012
PubMed

Insights

Genetic and epigenetic regulation of phosphoinositide 3-kinases (PI3K) are crucial in disease. This review details PI3K gene and epigenetic control in health and illness, highlighting open questions.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cellular Signaling

Background:

  • Phosphoinositide 3-kinases (PI3K) signaling is implicated in cancer, diabetes, and inflammation.
  • Understanding PI3K regulation is vital for disease treatment.
  • Genetic and epigenetic mechanisms controlling PI3K are increasingly recognized.

Purpose of the Study:

  • To review the genetic and epigenetic regulation of PI3K isoforms.
  • To explore the role of PI3K alterations in various diseases.
  • To highlight current knowledge gaps in PI3K regulation.

Main Methods:

  • Literature review of genetic and epigenetic mechanisms.
  • Analysis of PI3K isoform modulation in physiological and pathological conditions.
  • Synthesis of evidence on PI3K regulation in disease.

Main Results:

  • PI3K levels are modulated by gene copy number and transcription.
  • Epigenetic mechanisms, independent of DNA sequence, influence PI3K expression.
  • Altered PI3K regulation is linked to cancer, diabetes, and inflammation.

Conclusions:

  • Genetic and epigenetic factors significantly impact PI3K function.
  • Further research into PI3K regulation is needed for therapeutic strategies.
  • Understanding PI3K control is key to addressing major diseases.

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