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Updated: May 18, 2026

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
07:32

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

Fibroblast growth factor receptor inhibitors

Suneel B V S Kumar1, Lakshmi Narasu, Rambabu Gundla

  • 1GVK Biosciences Pvt. Ltd., Phase-1, Technocrats Industrial Estate, Balanagar 500037, Andhra Pradesh, India. suneelkumar.bvs@gmail.com

Current Pharmaceutical Design
|September 29, 2012
PubMed

Insights

Fibroblast growth factor receptors (FGFRs) are crucial in development and cancer. This review details FGFR1

Area of Science:

  • Oncology
  • Molecular Biology
  • Drug Discovery

Background:

  • Fibroblast growth factor receptors (FGFRs) are vital in embryonic development, angiogenesis, and cell regulation.
  • FGFR signaling is implicated in various cancers and tumor progression.
  • FGFR1's role in cancer metabolism is an emerging area of research.

Purpose of the Study:

  • To review recent advancements in understanding FGFR signaling in cancer metabolism.
  • To explore the mechanisms and binding modes of FGFR kinase inhibitors.
  • To highlight key structural classes of FGFR inhibitors for anticancer drug development.

Main Methods:

  • Literature review of recent findings on FGFRs in cancer.
  • Analysis of signaling pathways involving FGFR, PKM2, and cancer metabolism.
  • Examination of structural classes and binding modes of FGFR kinase inhibitors.

Main Results:

  • FGFRs mediate signaling pathways crucial for cancer metabolism.
  • FGFR1 plays a significant role in regulating cancer cell metabolism.
  • Various kinase inhibitors targeting FGFRs, including PD173074 and SU series, are under clinical investigation.

Conclusions:

  • Targeting FGFR signaling presents a promising strategy for anticancer drug development.
  • Understanding FGFR's role in cancer metabolism can lead to novel therapeutic approaches.
  • Further research into FGFR inhibitors and their mechanisms is essential for clinical translation.

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