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Updated: May 18, 2026
07:32
Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
Published on: September 30, 2019
Fibroblast growth factor receptor inhibitors
Suneel B V S Kumar1, Lakshmi Narasu, Rambabu Gundla
1GVK Biosciences Pvt. Ltd., Phase-1, Technocrats Industrial Estate, Balanagar 500037, Andhra Pradesh, India. suneelkumar.bvs@gmail.com
Current Pharmaceutical Design
|September 29, 2012
Summary
Fibroblast growth factor receptors (FGFRs) are crucial in development and cancer. This review details FGFR1
Area of Science:
- Oncology
- Molecular Biology
- Drug Discovery
Background:
- Fibroblast growth factor receptors (FGFRs) are vital in embryonic development, angiogenesis, and cell regulation.
- FGFR signaling is implicated in various cancers and tumor progression.
- FGFR1's role in cancer metabolism is an emerging area of research.
Purpose of the Study:
- To review recent advancements in understanding FGFR signaling in cancer metabolism.
- To explore the mechanisms and binding modes of FGFR kinase inhibitors.
- To highlight key structural classes of FGFR inhibitors for anticancer drug development.
Main Methods:
- Literature review of recent findings on FGFRs in cancer.
- Analysis of signaling pathways involving FGFR, PKM2, and cancer metabolism.
- Examination of structural classes and binding modes of FGFR kinase inhibitors.
Main Results:
- FGFRs mediate signaling pathways crucial for cancer metabolism.
- FGFR1 plays a significant role in regulating cancer cell metabolism.
- Various kinase inhibitors targeting FGFRs, including PD173074 and SU series, are under clinical investigation.
Conclusions:
- Targeting FGFR signaling presents a promising strategy for anticancer drug development.
- Understanding FGFR's role in cancer metabolism can lead to novel therapeutic approaches.
- Further research into FGFR inhibitors and their mechanisms is essential for clinical translation.
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