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Total synthesis of 7',8'-dihydroaigialospirol
Tsz-Ying Yuen1, Margaret A Brimble
1School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland, New Zealand.
Abstract:
A highly convergent total synthesis of 7',8'-dihydroaigialospirol is described. Key steps of the synthesis include a Nozaki-Hiyama-Kishi (NHK) coupling of an iodoalkyne with an advanced phthalide-aldehyde and a remarkable one-pot acid-mediated global deprotection/spiroacetalization.
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