Negative regulation of myeloid-derived suppressor cells in cancer
Peng Qu1, Kimberly C Boelte, P Charles Lin
1National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702, USA.
Abstract:
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells with suppressive function on immune response. In this review, we discuss recent studies about mechanisms of expansion and suppressive function of MDSCs during inflammation, infection and autoimmune diseases, as well as pro-angiogenic and pro-metastatic functions of these cells in tumor development. Further, we focus on novel studies of MDSCs and therapeutic approaches to eliminate these cells in cancer.
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