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Influenza virus infection in nonhuman primates
Erik A Karlsson1, Gregory A Engel, M M Feeroz
1St. Jude Children’s Research Hospital, Memphis, Tennessee, USA.
Emerging Infectious Diseases
|September 29, 2012
Summary
Influenza viruses were detected in macaques globally, indicating nonhuman primates may play a role in the spread of influenza. This finding prompts further research into their ecological significance for the virus.
Area of Science:
- Veterinary Virology
- Primate Immunology
- Infectious Disease Ecology
Background:
- Influenza viruses are highly adaptable respiratory pathogens with significant public health impact.
- The potential role of nonhuman primates in the natural circulation and evolution of influenza viruses remains largely unexplored.
Purpose of the Study:
- To investigate the prevalence and diversity of influenza virus infections in wild and captive macaques worldwide.
- To assess the serological evidence of influenza virus exposure in these nonhuman primate populations.
Main Methods:
- Conducted serological surveys analyzing antibody responses to influenza viruses in macaque populations.
- Performed swab studies for direct detection of influenza virus RNA in respiratory samples from macaques.
Main Results:
- Detected influenza virus and antibodies against influenza viruses in macaques from various geographical locations.
- The findings suggest widespread exposure and potential circulation of influenza viruses within macaque populations.
Conclusions:
- Nonhuman primates, specifically macaques, are susceptible to influenza virus infection.
- The presence of influenza viruses in macaques necessitates further investigation into their role in influenza ecology and potential for zoonotic transmission.
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