Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peptidoglycan Synthesis01:28

Peptidoglycan Synthesis

Structure of PeptidoglycanPeptidoglycan is a vital structural component of the bacterial cell wall, providing mechanical strength and shape to the cell. It consists of repeating units of two sugars—N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM)—linked by β-1,4 glycosidic bonds. These sugar chains are cross-linked by short peptide chains, forming a mesh-like polymer that surrounds the bacterial plasma membrane.Cytoplasmic Phase – Precursor SynthesisPeptidoglycan biosynthesis begins in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementation of BSH 2020 irradiation guidelines for children with DiGeorge syndrome.

Transfusion medicine (Oxford, England)·2026
Same author

Mental and Physical Health Predictors of Return-to-Work Outcomes among Individuals with Long COVID Symptoms.

International journal of behavioral medicine·2026
Same author

A comprehensive treatment algorithm for chronic pelvic pain patients: A perspective review and future guidelines.

Women's health (London, England)·2026
Same author

The NeuroBioBank whole-genome catalogue of human brain donors with central nervous system disorders.

Brain : a journal of neurology·2026
Same author

Evaluation of the Relationship between Vesicular Monoamine Transporter 2 (VMAT2) Inhibition and Neurologic Adverse Events in Approved Drugs.

ACS pharmacology & translational science·2026
Same author

CXCR4 antagonism corrects neutrophil abnormalities and reduces pneumonia severity in a pharmacological mouse model of CXCR2 loss-of-function-mediated neutropenia.

Frontiers in immunology·2025
Same journal

Discovery of a potent sGC stimulator with once-daily dosing potential for the treatment of hypertension.

Bioorganic & medicinal chemistry letters·2026
Same journal

OracleScreen-LILRB4 (HTS-Oracle v3): machine learning-guided discovery of myeloid immune checkpoint binders validated in patient-derived cells.

Bioorganic & medicinal chemistry letters·2026
Same journal

Rational design and N-terminal acylation of a lactam-cyclized 11-residue antimicrobial peptide for improved antibacterial potency.

Bioorganic & medicinal chemistry letters·2026
Same journal

Rational design, synthesis, and biological evaluation of chalcone hybrids including benzoylpiperazin (phenylacetylpiperazin)-thiophene as anti- Alzheimer's agents.

Bioorganic & medicinal chemistry letters·2026
Same journal

New aminopiperidine-azoles as antifungal agents against Candida albicans with mechanistic insights into the cAMP-PKA pathway.

Bioorganic & medicinal chemistry letters·2026
Same journal

Novel 1H-pyrrole-2,5-dione derivatives as potential anti-diabetic agents: design, synthesis, in vitro, in ovo, and molecular docking studies.

Bioorganic & medicinal chemistry letters·2026
See all related articles

Related Experiment Video

Updated: May 18, 2026

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials
08:55

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials

Published on: June 25, 2018

Formylated polyamines as peptidomimetics.

Sacha Javor1, Aaron Janowsky, Robert Johnson

  • 1The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Bioorganic & Medicinal Chemistry Letters
|September 29, 2012
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel peptidomimetic using a modified retro-inverso sequence to mimic natural peptide ligands. This new molecule showed selective activity at mu-opioid receptors.

More Related Videos

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
13:37

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library

Published on: June 20, 2014

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

Related Experiment Videos

Last Updated: May 18, 2026

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials
08:55

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials

Published on: June 25, 2018

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
13:37

Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library

Published on: June 20, 2014

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
13:42

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

Area of Science:

  • Medicinal Chemistry
  • Peptide Science
  • Neuropharmacology

Background:

  • Natural peptide ligands play crucial roles in biological systems.
  • Developing stable and selective mimics of peptide ligands is a significant challenge in drug discovery.
  • Opioid receptors are key targets for pain management and other therapeutic areas.

Purpose of the Study:

  • To design and synthesize a novel peptidomimetic construct.
  • To imitate the function of a natural peptide ligand using a modified retro-inverso sequence.
  • To evaluate the activity and selectivity of the synthesized peptidomimetic.

Main Methods:

  • Design of a modified retro-inverso peptide sequence.
  • Chemical synthesis of the peptidomimetic.
  • In vitro assays to determine receptor binding and activity.

Main Results:

  • Successful synthesis of a peptidomimetic based on leucine enkephalin.
  • The peptidomimetic demonstrated biological activity at a concentration of 400 nM.
  • The compound exhibited selectivity for the mu-opioid receptor.

Conclusions:

  • Modified retro-inverso sequences are effective for creating functional peptide mimics.
  • The synthesized peptidomimetic represents a promising lead compound for targeting mu-opioid receptors.
  • This approach offers a new strategy for developing peptide-based therapeutics.