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IQGAP1: A microtubule-microfilament scaffolding protein with multiple roles in nerve cell development and synaptic
Ignacio Jausoro1, Iván Mestres, Mónica Remedi
1Laboratory of Neurobiology, Instituto Investigación Médica Mercedes y Martín Ferreyra (INIMEC-CONICET), Córdoba, Argentina.
Abstract:
In this article, we review our current understanding of the biology of IQ domain-containing GTPase-Activating Protein 1, IQGAP1, a scaffolding protein with multiple binding partners, which is widely expressed among different cell types, including neurons, and capable of linking Rho-GTPase signaling with cytosleletal elements and environmental cues. Interestingly, a series of recent studies suggest that IQGAP family members have an important role in neuronal development, synaptic plasticity and nervous system disorders involving alterations in spine density.
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