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Aging influences central motor conduction less than peripheral motor conduction: a transcranial magnetic stimulation
Hideyuki Matsumoto1, Yuko Konoma, Takahiro Shimizu
1Department of Neurology, Japanese Red Cross Medical Center, 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935, Japan. hideyukimatsumoto.jp@gmail.com
Introduction:
In this study we investigated the effects of aging on corticospinal tract conduction by measuring the corticoconus motor conduction time (CCCT).
Methods:
Motor evoked potentials were recorded from the right tibialis anterior muscle in 100 healthy volunteers. To activate the most proximal part of the cauda equina, magnetic stimulation was performed using a MATS coil over the L1 spinous process (L1-level latency). Transcranial magnetic stimulation of the motor cortex was also conducted (cortical latency). To obtain the CCCT, the L1-level latency was subtracted from the cortical latency.
Results:
Age was significantly correlated with L1-level latency, but it was not significantly correlated with CCCT.
Conclusions:
CCCT is the most direct indicator of corticospinal tract conduction, whereas L1-level latency reflects whole peripheral motor conduction. Central motor conduction was found to be relatively less affected by aging compared with peripheral motor conduction.
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