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[Changes in the affinity of oxygen for hemoglobin during general anesthesia]
Annales De L'Anesthesiologie Francaise
|January 1, 1977
Summary
General anesthesia reduces hemoglobin-oxygen affinity by lowering 2,3-diphosphoglycerate (2,3-DPG) levels and body temperature. Hypothermia and blood transfusions significantly impact oxygen affinity during surgery.
Area of Science:
- Physiology
- Anesthesiology
- Biochemistry
Context:
- General anesthesia can alter oxygen transport dynamics.
- Intraerythrocyte 2,3-diphosphoglycerate (2,3-DPG) levels and body temperature are known to influence hemoglobin-oxygen affinity.
Purpose:
- To investigate the impact of general anesthesia on hemoglobin-oxygen affinity.
- To determine the role of 2,3-DPG levels and hypothermia in altering this affinity during prolonged anesthesia.
Summary:
- A study on 15 adult subjects undergoing general anesthesia showed a significant reduction in P50 (hemoglobin-oxygen affinity) post-anesthesia.
- This reduction correlated with decreased intraerythrocyte 2,3-DPG levels and was further influenced by hypothermia and the volume of blood transfused.
Impact:
- Findings highlight the importance of monitoring and managing body temperature and blood transfusion parameters during general anesthesia.
- Results suggest potential implications for oxygen delivery to tissues in patients under anesthesia, especially when hypothermia is present.