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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Parallel solid-phase synthesis of diaryltriazoles
Matthias Wrobel1, Jeffrey Aubé, Burkhard König
1Fakultät für Chemie und Pharmazie, Universität Regensburg, D-93040 Regensburg, Germany.
Abstract:
A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a parallel fashion with in many cases good to excellent yields. Substituted diaryltriazoles resemble a molecular structure similar to established terphenyl-alpha-helix peptide mimics and have therefore the potential to act as selective inhibitors for protein-protein interactions.
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