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Updated: May 18, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
Published on: November 8, 2012
Response to comment on "the geometric structure of the brain fiber pathways"
Van J Wedeen1, Douglas L Rosene, Ruopeng Wang
1Department of Radiology, Massachusetts General Hospital, Harvard Medical School and the Martinos Center for Biomedical Imaging, Building 129 13th Street, 2nd floor, Charlestown, MA 02129, USA. van@nmr.mgh.harvard.edu
Abstract:
In response to Catani et al., we show that corticospinal pathways adhere via sharp turns to two local grid orientations; that our studies have three times the diffusion resolution of those compared; and that the noted technical concerns, including crossing angles, do not challenge the evidence of mathematically specific geometric structure. Thus, the geometric thesis gives the best account of the available evidence.
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