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Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Mismatch Repair01:36

Mismatch Repair

Overview

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Updated: May 18, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Community associated methicillin-resistant Staphylococcus aureus.

R Mertens1, L Seyler, P Lacor

  • 1Department of Internal Medicine, Infectious Diseases Unit, UZ Brussel, Belgium.

Acta Clinica Belgica
|October 2, 2012
PubMed
Summary
This summary is machine-generated.

Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging infectious pathogen causing severe infections in healthy individuals. This article reviews current knowledge and clinical management of CA-MRSA.

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Last Updated: May 18, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

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Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus
09:03

Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus

Published on: September 5, 2013

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Emergence of unique Staphylococcus aureus strains with combined virulence and antibiotic resistance.
  • Increasing prevalence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections.

Observation:

  • CA-MRSA strains are associated with severe community-acquired infections.
  • These infections disproportionately affect healthy, younger individuals.
  • CA-MRSA is a significant cause of outpatient staphylococcal infections, particularly in the USA.

Findings:

  • Unique CA-MRSA strains possess specific virulence factors and antibiotic resistance.
  • These strains are responsible for a substantial proportion of staphylococcal infections in outpatient settings.
  • Severe CA-MRSA infections have been reported in both the USA and Belgium.

Implications:

  • CA-MRSA represents a growing public health concern due to its emergent nature.
  • Understanding CA-MRSA epidemiology and characteristics is crucial for effective clinical management.
  • Timely diagnosis and appropriate treatment strategies are essential to combat CA-MRSA infections.