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Updated: May 18, 2026

Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
Published on: November 10, 2013
[Advance of studies on bioactivity of flavonoid-metal complexes]
Yanji Liu1, Xiaoyan He, Hua Zuo
1College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China. liuyanji111@163.com
Abstract:
The flavonoid-metal complexes showed obviously stronger bioactivities such as antibiosis, antivirus, anti-inflammatory, anti-tumor and anti-free-radical, possibly because of the stronger binding force caused by the change in complex structure and accessibility to target spots, or the synergy effect between flavonoids and metallic ions. This essay summarizes studies on bioactivity and mechanism of flavonoid-metal complexes, in order to provide reference for in-depth study and development on effective constituents contained in flavonoid traditional Chinese medicines.
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