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[Multi-channel analysis and comparison on absorption difference between paeoniflorin and Paeonia lactiflora extracts]
1Key Laboratory of Chinese Medicine New Drug Delivery Systems, Jiangsu Institute of Traditional Chinese Medicine, Key Laboratory of Chinese Medicine Oral Formulations Drug Delivery Systems, State Administration of Traditional Chinese Medicine, Nanjing 210028, China. ychen202@yahoo.com.cn
Summary
Paeonia lactiflora extracts enhance paeoniflorin absorption in rat intestines compared to the paeoniflorin monomer. However, overall paeoniflorin absorption remains poor, limiting short-term increases in bile and plasma concentrations.
Area of Science:
- Pharmacology and Pharmacokinetics
- Natural Product Chemistry
- Gastrointestinal Absorption
Background:
- Paeoniflorin is a key active compound in Paeonia lactiflora.
- Understanding the absorption of paeoniflorin and its effects within herbal extracts is crucial for its therapeutic application.
- Variations in absorption can occur due to the complex matrix of herbal extracts.
Purpose of the Study:
- To quantitatively compare the intestinal absorption of paeoniflorin monomer versus Paeonia lactiflora extract.
- To investigate the influence of other components in Paeonia lactiflora extract on paeoniflorin absorption.
- To analyze absorption across different segments of the rat intestine.
Main Methods:
- Utilized a multi-channel rat intestinal perfusion model.
- Collected intestinal perfusate, bile, and plasma samples for analysis.
- Incorporated intestinal enzyme incubation and partition coefficient determination for comprehensive assessment.
Main Results:
- Paeonia lactiflora extract demonstrated significantly higher effective permeability (Peff*) of paeoniflorin than the monomer, particularly in the jejunum and ileum (P < 0.05).
- Both forms exhibited low overall Peff* values, ranging from 0.209-0.290 for the monomer and 0.252-0.333 for the extract.
- No detectable levels of paeoniflorin or its metabolites were found in bile, plasma, or enzyme incubation samples.
Conclusions:
- Components within Paeonia lactiflora extract enhance paeoniflorin's intestinal absorption.
- Despite enhanced absorption, paeoniflorin's inherent poor bioavailability limits rapid increases in systemic or biliary concentrations.
- Further research may be needed to optimize paeoniflorin delivery and efficacy.
