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Early growth velocities and weight gain plasticity improve linear growth in Peruvian infants
Lora L Iannotti1, Nelly Zavaleta, Clara Huasaquiche
1Institute for Public Health, Washington University in St. Louis, St. Louis, Missouri, USA.
Insights
Early infant growth velocity, especially weight gain plasticity, is crucial for predicting a child's length and weight at 12 months. Understanding these patterns helps identify potential long-term health issues.
Area of Science:
- Pediatric Growth and Development
- Nutritional Epidemiology
- Infant Health
Background:
- Growth velocity patterns can indicate adverse responses to environmental factors.
- Early infancy is a critical period for growth and development.
- Understanding growth determinants is vital for long-term health outcomes.
Purpose of the Study:
- To investigate growth velocities in Peruvian infants in relation to anthropometric outcomes at 12 months.
- To identify determinants of growth velocities during critical infant periods.
- To examine the impact of early growth dynamics on attained size.
Main Methods:
- Longitudinal study of 259 Peruvian infants from 1995-1997.
- Monthly anthropometric measurements over the first year of life.
- Analysis of incremental velocity, proportional changes, and individual velocity variability.
Main Results:
- Early growth velocities and weight gain variability positively predicted attained length and weight at 12 months.
- Growth velocities in the first month were significant predictors.
- Growth pace decelerated exponentially through infancy, influenced by birth size.
Conclusions:
- Early growth velocities and weight gain plasticity are important for attained anthropometric outcomes.
- Growth velocity patterns provide insights into infant health and development.
- This study highlights the significance of monitoring early growth dynamics.
Abstract:
Growth velocity patterns have the potential to signal unhealthy responses to environmental insults with long-term consequences. We aimed to investigate velocities in Peruvian infants (n = 259) in relation to attained anthropometric outcomes at 12 months and to identify determinants of velocities during critical periods of infancy. From 1995 to 1997, a randomised controlled trial of maternal zinc supplementation was conducted in a peri-urban slum area of Lima. Infants were followed monthly through 1 year on a range of anthropometric measures. Three types of velocity variables were studied: (1) incremental velocity (1 months and 3 months); (2) proportional changes (% of total size gained/month); and (3) individual velocity variability [standard deviation (SD) of individual child incremental velocities]. Mean individual child SD of weight velocity was 417 g (±126). In multivariate ordinary least squares regression analyses, growth velocities in month 1 and individual weight velocity variability positively predicted attained length and weight by 12 months. Panel regression by generalised least-squares with random effects of length and weight velocities confirmed the exponentially decelerating pace of growth through infancy and the importance of birth size in driving this trajectory. This study contributes evidence to support the importance of early growth velocities and greater degrees of weight gain plasticity for attained length and weight.
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