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Updated: May 18, 2026
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Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy Model in Mice
Published on: February 10, 2023
Single-stitch telescopic bilioenterostomy in an animal model
Dionisios Vrochides1, Achilleas Ntinas, Dimitrios Kardassis
1Center for HPB Surgery, “Geniki Kliniki” General Hospital, Thessaloniki, Greece. vrochides@yahoo.com
Summary
A novel telescopic bilioenterostomy technique using a single stitch and self-disposable stent proved safe and effective in an animal model. This hepato-pancreato-biliary surgery innovation shows promise for simplifying complex anastomoses.
Area of Science:
- Hepatobiliary surgery
- Surgical innovation
- Anastomotic techniques
Background:
- End-to-side biliodigestive anastomosis is common but technically challenging in hepato-pancreato-biliary surgery.
- Telescopic ureterovesical anastomosis is a known technique in transplant surgery.
Purpose of the Study:
- To investigate the feasibility of a telescopic biliodigestive anastomosis.
- To evaluate a novel single-stitch technique with a self-disposable stent.
Main Methods:
- Eleven pigs were divided into technique-standardization (n=8) and main study (n=3) groups.
- A single-stitch telescopic anastomosis with a self-disposable stent was performed in the main study group.
- Animals were followed for 4 weeks, with cholangiograms, tissue samples, and biological data collected.
Main Results:
- No bilomas or functional biliary strictures were observed in the main study group.
- Light microscopy showed intestinal metaplasia of the biliary epithelium within the telescoped segment.
Conclusions:
- Telescopic bilioenterostomy with a single pull-through stitch and self-disposable stent is quick, reproducible, and appears complication-free in animal models.
- Further studies with longer follow-up are needed to assess risks of delayed cholangitis or adenocarcinoma.
