Large histiocytes in the choroid of leukemic patients

We identified large histiocytes as a prominent feature in the choroid of eyes obtained at autopsy in seven of nine patients who died of leukemia. The eyes of four of the seven patients affected had leukemic choroidal infiltrates, and a majority had similar-appearing histiocytes identified in spleen or bone marrow. The significance of these cells is undetermined; we postulate that these macrophages are ingesting debris of degenerating leukemic cells.