Genetic polymorphism of PRKCDBP is associated with an increased risk of endometrial cancer
Seo-Yun Tong1, Jong-Min Lee, Kyung-Do Ki
1Department of Obstetrics and Gynecology, School of Medicine, Kyung Hee University, Seoul, South Korea.
Abstract:
PRKCDBP is a putative tumor suppressor located at 11p15.4, where frequent genomic loss has been observed in human cancers. We explored the possible association between an intra-exonic single nucleotide polymorphism (SNP), rs1051992, that results in a Leu to Pro substitution, and risk for endometrial carcinogenesis. We assessed the genotype of rs1051992 in endometrial cancer tissues from 147 patients and normal endometrial tissue from 191 healthy individuals by restriction endonuclease PvuII-based genotyping. Allele frequencies in the cancer specimens were compared with those in the healthy controls. We also evaluated the association between polymorphisms at this locus and histopathological features of endometrial cancer.
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