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Related Concept Videos

The Cochlea01:13

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.

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Related Experiment Video

Updated: May 18, 2026

Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats
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Auditory Brainstem Response and Outer Hair Cell Whole-cell Patch Clamp Recording in Postnatal Rats

Published on: May 24, 2018

Cochlin expression in the rat perilymph during postnatal development.

Kyoko Shiiba1, Susumu Shindo, Tetsuo Ikezono

  • 1Department of Otorhinolaryngology, Nippon Medical School, Tokyo, Japan.

Acta Oto-Laryngologica
|October 2, 2012
PubMed
Summary
This summary is machine-generated.

Cochlin isoform levels in rat perilymph change during development, with p63s decreasing and Cochlin-tomoprotein (CTP) increasing postnatally. This offers insights into cochlin function and inner ear disease pathogenesis.

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Last Updated: May 18, 2026

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09:23

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Published on: January 1, 2016

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Published on: November 2, 2014

Area of Science:

  • Otorhinolaryngology
  • Developmental Biology
  • Molecular Biology

Background:

  • Cochlin is implicated in inner ear pathologies.
  • Previous studies noted altered cochlin isoform levels in developing inner ear tissues.

Purpose of the Study:

  • To investigate cochlin isoform expression in rat perilymph during postnatal development.
  • To correlate perilymphatic cochlin isoform levels with Coch gene mRNA expression.

Main Methods:

  • Western blot analysis of cochlin isoforms in rat perilymph.
  • Real-time PCR to quantify Coch mRNA expression in developing rat inner ear.

Main Results:

  • Perilymphatic p63s expression peaked at postnatal day 12 and declined thereafter.
  • Cochlin-tomoprotein (CTP) expression was lowest at postnatal day 12, increasing by postnatal day 24.
  • COCH mRNA was detected from postnatal day 3, peaking around day 15, then decreasing by day 70.

Conclusions:

  • Dynamic changes in cochlin isoforms within the perilymph occur during postnatal development.
  • These findings may illuminate cochlin's role and the mechanisms underlying inner ear diseases.