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Emerging adverse cutaneous drug reactions
Joshua W Hagen1, Cynthia M Magro, A Neil Crowson
1Tri-Institutional MD-PhD Program, Weill Medical College of Cornell University, New York, NY 10065, USA.
Dermatologic Clinics
|October 2, 2012
Summary
Biological agents treat chronic diseases but can cause skin reactions. This review covers these adverse cutaneous effects, their mechanisms, and how to predict and minimize them.
Area of Science:
- Dermatology
- Pharmacology
- Immunology
Background:
- Biological agents are increasingly used for chronic diseases.
- Physicians are familiar with desired and adverse events from these treatments.
- Dermatologists commonly see cutaneous drug reactions to biological agents.
Purpose of the Study:
- To review adverse cutaneous effects of biological agents.
- To discuss the underlying mechanisms of these reactions.
- To explore methods for predicting and minimizing these side effects.
Main Methods:
- Literature review of adverse cutaneous events associated with biological agents.
- Analysis of reported side effects and their frequency.
- Discussion of proposed pathomechanisms.
Main Results:
- Biological agents can cause a wide spectrum of skin reactions.
- Understanding mechanisms aids in predicting and managing reactions.
- Proactive strategies can minimize the occurrence and severity of cutaneous adverse events.
Conclusions:
- Adverse cutaneous reactions are a significant concern with biological therapies.
- Further research into predictive markers and preventative strategies is warranted.
- Dermatologists play a crucial role in managing these drug-induced skin conditions.
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