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Visual function deficits in glaucoma. Electroretinogram pattern and luminance nonlinearities.

J V Odom1, J G Feghali, J C Jin

  • 1Department of Ophthalmology, West Virginia University School of Medicine, Morgantown 26506.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|February 1, 1990
PubMed
Summary
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Glaucoma patients show abnormal pattern electroretinogram (PERG) and flicker electroretinogram (fERG) responses. Both conditions exhibited reduced electroretinogram amplitudes, confirming visual pathway dysfunction in glaucoma.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Visual Electrophysiology

Background:

  • The pattern electroretinogram (PERG) is known to be abnormal in glaucoma.
  • Nonlinear luminance responses may contribute to PERG findings in glaucoma.

Purpose of the Study:

  • To investigate glaucoma's effect on PERG component waves.
  • To determine if nonlinear components of the flicker electroretinogram (fERG) are abnormal in glaucoma.

Main Methods:

  • Tested 35 subjects under four conditions: 10- and 20-Hz flicker, and 4- and 10-Hz pattern reversal.
  • Recorded only even harmonics for electroretinogram analysis.
  • Compared electroretinogram amplitudes between glaucoma patients, those suspected of glaucoma, and normal subjects.

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Main Results:

  • Glaucoma patients exhibited reduced electroretinogram amplitudes across all tested measures compared to normal subjects.
  • Individuals suspected of having glaucoma showed intermediate electroretinogram amplitudes.
  • The most significant amplitude reductions were observed in the 10-Hz fERG and 4-Hz PERG.

Conclusions:

  • Confirms existing evidence of PERG abnormalities in glaucoma.
  • Reveals novel evidence of fERG abnormalities in glaucoma.
  • Suggests both PERG and fERG are sensitive indicators of visual pathway dysfunction in glaucoma.