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Related Concept Videos

Phases of Wound Repair01:28

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Related Experiment Video

Updated: May 18, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Tissue response during self-ligating treatment.

Laura Bolamperti1, Paola Montanari, Luca Levrini

  • 1University of Insubria, Department of Orthodontics, Varese, Italy.

Progress in Orthodontics
|October 2, 2012
PubMed
Summary
This summary is machine-generated.

This study found no significant differences in tissue response, measured by lactate dehydrogenase (LDH) activity in gingival crevicular fluid (GCF), between superelastic and thermoactive archwires used with self-ligating brackets during orthodontic tooth movement.

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Published on: June 11, 2017

Area of Science:

  • Orthodontics
  • Biomaterials
  • Periodontology

Background:

  • Orthodontic tooth movement involves inflammatory tissue reactions in the periodontal ligament, influenced by applied forces.
  • Self-ligating brackets reduce sliding resistance and required forces, potentially improving tissue response.

Purpose of the Study:

  • To evaluate lactate dehydrogenase (LDH) activity in gingival crevicular fluid (GCF) during orthodontic tooth movement with self-ligating brackets.

Main Methods:

  • Forty patients were treated with Quick 2.0 or Smart Clip self-ligating brackets and superelastic or thermoactive archwires.
  • GCF was collected from specific teeth at baseline, 1 hour, and on days 7, 28, and 42 post-bonding.
  • LDH activity in GCF samples was analyzed using a specific assay.

Main Results:

  • Statistical analysis revealed no significant differences in LDH activity between teeth treated with self-ligating brackets and control teeth.
  • No significant variations in LDH activity were observed between the different types of self-ligating brackets or archwires used.

Conclusions:

  • The study indicates no significant difference in tissue response between superelastic and thermoactive archwires when used with self-ligating brackets.
  • These findings suggest comparable tissue biocompatibility for the evaluated archwire materials in this orthodontic context.