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Related Concept Videos

Routes of Persuasion02:20

Routes of Persuasion

Persuasion is the process of changing our attitude toward something based on some kind of communication. Much of the persuasion we experience comes from outside forces. How do people convince others to change their attitudes, beliefs, and behaviors? What communications do you receive that attempt to persuade you to change your attitudes, beliefs, and behaviors?
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Translation Produces the Building Blocks of Life
Translation01:31

Translation

Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are called the...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life

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Related Experiment Video

Updated: May 18, 2026

In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)
06:48

In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)

Published on: August 1, 2025

All things to all people.

Trevor D Littlewood1, Peter Kreuzaler, Gerard I Evan

  • 1Department of Biochemistry, University of Cambridge, UK.

Cell
|October 2, 2012
PubMed
Summary
This summary is machine-generated.

The Myc protein, a key factor in cell growth, doesn't create new gene targets. Instead, it amplifies the activity of genes already being transcribed, offering new insights into cancer research.

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Area of Science:

  • Molecular Biology
  • Cancer Research
  • Gene Regulation

Background:

  • The Myc protein is a crucial regulator of cell proliferation, but its precise functions and target genes, especially in cancer, remain poorly understood.
  • Previous research has faced challenges in identifying definitive Myc target genes due to context-specific activities and experimental limitations.

Discussion:

  • This study resolves the Myc enigma by demonstrating its role as a transcriptional amplifier, rather than a direct gene activator.
  • The findings suggest Myc enhances the output of transcriptionally active genes, providing a new framework for understanding its oncogenic potential.

Key Insights:

  • Myc functions by increasing the transcriptional output of already active genes.
  • This mechanism explains the context-dependent effects of Myc observed in previous studies.
  • Identifies a novel mechanism for Myc-mediated gene regulation relevant to cancer biology.

Outlook:

  • Further research can explore therapeutic strategies targeting Myc's amplification function in various cancers.
  • This discovery opens new avenues for investigating Myc's role in normal development and disease.
  • Future studies will focus on the specific molecular mechanisms underlying Myc's amplification activity.