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Absence of viruses in amniotic fluid of women with PPROM: a case series

Amber Naresh1, Hyagriv Simhan

  • 1University of Pittsburgh, Department of Obstetrics, Gynecology, & Reproductive Sciences, Pittsburgh, PA 15213, USA. anaresh@tulane.edu

Journal of Reproductive Immunology
|October 2, 2012
PubMed

Insights

This study found no evidence of viral genomic content in amniotic fluid samples from women with preterm premature rupture of membranes (PPROM). Viral infection was not associated with PPROM or intrauterine inflammation in this case series.

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Neonatology

Background:

  • Preterm birth and preterm premature rupture of membranes (PPROM) are linked to intrauterine inflammation.
  • Bacterial infection is often implicated, but viral causes are less understood.

Observation:

  • A case series of 13 women with PPROM was analyzed.
  • Amniotic fluid was tested via PCR for common viruses (HSV, adenovirus, CMV, HPV, etc.).
  • Bacterial cultures and inflammatory markers were also assessed.

Findings:

  • No viral genomic content was detected in any amniotic fluid samples.
  • Bacterial infections were present in 46% of the samples.
  • Viral infection was not associated with PPROM in this cohort.

Implications:

  • Viral infection does not appear to be a significant factor in PPROM.
  • Further research is needed to fully understand the etiology of PPROM and associated inflammation.
  • Focus may remain on bacterial causes and inflammatory pathways.

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