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Ischemic Heart Disease: Overview

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...

Coronary Artery Disease V: Interprofessional Care

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...

Acute Coronary Syndrome IV: Interprofessional Care

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...

Cardiomyopathy V: Interprofessional Care

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...

Cardiomyopathy II: Dilated Cardiomyopathy

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...

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Related Experiment Video

Updated: May 18, 2026

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

Published on: May 26, 2023

[Cell therapy for ischemic heart disease].

Carlos David Escobedo-Uribe¹, Adriana Elizabeth Monsiváis-Urenda, Juan Manuel López-Quijano

¹Instituto Nacional de Cardiología Ignacio Chávez, México D.F., México. cardieu@hotmail.com

Archivos De Cardiologia De Mexico

|October 2, 2012

Summary

Stem cell therapy offers a promising approach for myocardial regeneration in ischemic heart disease, aiming to improve heart function and patient survival. Research explores its potential benefits and clarifies remaining questions for clinical application.

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Last Updated: May 18, 2026

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Published on: May 28, 2019

Area of Science:

Regenerative Medicine
Cardiovascular Research
Stem Cell Biology

Context:

Ischemic heart disease is a major global cause of mortality and heart failure.
Developing novel therapeutic strategies is crucial for reducing complications and improving outcomes.
Myocardial regeneration using progenitor cells is a key research area.

Purpose:

To explore the scientific principles underpinning stem cell therapy for ischemic heart disease.
To review current clinical evidence on the efficacy of regenerative medicine in heart disease.
To identify and discuss unresolved controversies regarding its short- and long-term clinical utility.

Summary:

Stem cell therapy is investigated for myocardial regeneration to enhance systolic and diastolic function in ischemic heart disease patients.
Worldwide studies, both human and animal, are assessing the effectiveness of stem cells in managing ischemic heart disease.
Regenerative therapy is emerging as a novel treatment with theoretical advantages and a favorable safety profile.

Impact:

Potential to decrease mortality and long-term complications in patients with ischemic heart disease.
Offers a novel therapeutic tool with substantial theoretical benefits and few side effects.
Aims to improve survival rates and cardiac function in patients suffering from heart failure due to ischemia.