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A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats
Shivika Rai1, Pradeep K Kamat, Chandishwar Nath
1Division of Pharmacology, CSIR, Central Drug Research Institute, Lucknow (U.P.), 226001, India.
Abstract:
Present study was designed to investigate the status of neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats. STZ produced significant increase in proinflammatory cytokines (TNF-α and IL-1β), ROS, nitrite and mRNA and protein expression of iNOS and nNOS indicating a state of neuroinflammation in rat brain which was significantly prevented by Memantine and Ibuprofen treatment. STZ also significantly altered NMDA subunits, NR2A and NR2B protein and mRNA expression which were restored by Memantine only. The results suggest that neuroinflammatory markers might be involved in memory impairment via modulating the NMDA receptor in STZ induced memory impaired rats.
