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Related Concept Videos

Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Gastritis II: Pathophysiology01:26

Gastritis II: Pathophysiology

The pathophysiology of gastritis begins with the colonization of the stomach lining by Helicobacter pylori (H. pylori). This bacterium spreads mainly via the oral-oral route through saliva or shared utensils, and can also be transmitted in overcrowded or unhygienic environments through contaminated water, despite its brief survival outside the body.ColonizationOnce ingested, H. pylori enters the stomach and begins colonization by navigating through the mucus layer lining the stomach wall. It...
Gastritis-I: Introduction and Types01:27

Gastritis-I: Introduction and Types

Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
Pyloric Obstruction01:11

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...

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Related Experiment Video

Updated: May 18, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Primary gastric synovial sarcoma.

Chung-Chieh Wang1, Meng-Che Wu, Ming-Tsan Lin

  • 1Department of Pathology, National Taiwan University Hospital, Medical College, National Taiwan University, Taipei, Taiwan.

Journal of the Formosan Medical Association = Taiwan Yi Zhi
|October 2, 2012
PubMed
Summary
This summary is machine-generated.

Monophasic synovial sarcoma, a rare gastric tumor, was diagnosed in a 38-year-old woman using molecular diagnostics. This case highlights the challenges in identifying these soft tissue neoplasms in unusual locations.

Related Experiment Videos

Last Updated: May 18, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Area of Science:

  • Oncology
  • Pathology
  • Molecular Diagnostics

Background:

  • Synovial sarcoma is a soft tissue neoplasm with biphasic or monophasic histological patterns.
  • Monophasic synovial sarcoma, particularly in rare sites like the gastrointestinal tract, presents diagnostic challenges.
  • Molecular diagnostic techniques are crucial for accurate diagnosis, especially for challenging cases.

Observation:

  • A case report of a 38-year-old woman with primary gastric monophasic synovial sarcoma is presented.
  • The tumor was confirmed via reverse transcriptase polymerase chain reaction, identifying the t(X;18) (SYT-SSX1) translocation.
  • Gastric synovial sarcomas are exceedingly rare, with only 11 previously reported cases.

Findings:

  • The study confirms a rare instance of monophasic synovial sarcoma originating in the stomach.
  • Molecular analysis, specifically the SYT-SSX1 translocation, was key to the diagnosis.
  • The rarity of gastric synovial sarcoma underscores the need for advanced diagnostic methods.

Implications:

  • This case emphasizes the importance of considering rare diagnoses like synovial sarcoma in gastric tumors.
  • Molecular pathology plays a vital role in diagnosing challenging soft tissue neoplasms.
  • Further research into the pathogenesis and clinical behavior of gastric synovial sarcoma is warranted.