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Nuclear quadrupole resonance characterization of carbamazepine cocrystals
1Jozef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia. janez.seliger@fmf.uni-lj.si
Abstract:
Nuclear quadrupole resonance (NQR) is used as a method for the characterization of cocrystals and crystal polymorphs. (14)N NQR spectra of several cocrystals of carbamazepine have been measured together with the (14)N NQR spectra of cocrystal formers. The results show that the (14)N NQR spectrum of a cocrystal and the (14)N NQR spectra of cocrystal formers differ well outside the experimental resolution. It is further described how the NQDR techniques, that have been used to measure the (14)N NQR frequencies, can be used to check the homogeneity of a polycrystalline sample and to monitor the stability of a metastable crystal polymorph.
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