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Updated: May 18, 2026

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
Published on: April 12, 2024
Recent findings in chronic obstructive pulmonary disease by using quantitative computed tomography
Nguyen Van Tho1, Hiroshi Wada, Emiko Ogawa
1Division of Respiratory Medicine, Department of Medicine, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan.
Quantitative CT scans offer a noninvasive method to assess chronic obstructive pulmonary disease (COPD) by measuring emphysema and airway dimensions. This complements traditional lung function tests for better COPD management and research.
Area of Science:
- Pulmonary Medicine
- Radiology
- Medical Imaging
Background:
- Chronic obstructive pulmonary disease (COPD) involves irreversible airflow limitation due to airway remodeling and emphysema.
- Forced expiratory volume in 1s (FEV(1)) is standard for COPD assessment but has limitations.
- Noninvasive methods are needed to complement FEV(1) for evaluating COPD treatments and pathogenesis.
Purpose of the Study:
- To review recent advances in using quantitative computed tomography (CT) for COPD assessment.
- To highlight how quantitative CT complements traditional pulmonary function tests.
- To discuss the role of quantitative CT in COPD phenotyping and research.
Main Methods:
- Review of recent literature on quantitative CT applications in COPD.
- Analysis of associations between quantitative CT measures (emphysema extent, airway dimensions) and COPD characteristics.
- Discussion of CT-based COPD phenotyping.
Main Results:
- Quantitative CT measures correlate with morphological and functional changes in COPD.
- CT-derived emphysema extent and airway dimensions are linked to clinical symptoms.
- Quantitative CT aids in phenotyping COPD for interventional and genotypic studies.
Conclusions:
- Quantitative CT is a valuable noninvasive tool for COPD assessment, complementing FEV(1).
- CT-based phenotyping advances COPD research and understanding.
- Further research utilizing quantitative CT findings is warranted for improved COPD management.
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