Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The complement component C4 of mammals.

A W Dodds1, S K Law

  • 1Department of Biochemistry, University of Oxford, U.K.

The Biochemical Journal
|January 15, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Are face masks useful for limiting the spread of COVID-19?

Hong Kong medical journal = Xianggang yi xue za zhi·2020
Same author

Is reinfection possible after recovery from COVID-19?

Hong Kong medical journal = Xianggang yi xue za zhi·2020
Same author

Cigarette smoking and glaucoma in the United States population.

Eye (London, England)·2018
Same author

Differences in the compliance with hospital infection control practices during the 2009 influenza H1N1 pandemic in three countries.

The Journal of hospital infection·2012
Same author

Comparison of long-term surgical success of Ahmed Valve implant versus trabeculectomy in open-angle glaucoma.

The British journal of ophthalmology·2009
Same author

Acupuncture for glaucoma.

The Cochrane database of systematic reviews·2007

The evolution of the complement component C4 (C4) gene locus was studied in mammals. Findings suggest C4 gene duplication is ancient or occurred multiple times across mammalian evolution.

Area of Science:

  • Immunogenetics
  • Evolutionary biology
  • Complement system

Background:

  • The human complement component C4 (C4) gene locus is duplicated within the HLA class III region, producing C4A and C4B with distinct activities.
  • Mouse C4 locus is also duplicated, but one gene produces a related protein, sex-limited protein (Slp), not active C4.

Purpose of the Study:

  • To investigate the evolutionary history of the duplicated C4 locus.
  • To understand the divergence of C4 gene functions across mammalian species.

Main Methods:

  • Purification of C4 from various mammalian species.
  • Testing the binding specificities of purified C4 proteins.

Main Results:

  • Chimpanzees and rhesus monkeys exhibit two C4 types, similar to human C4A and C4B.

Related Experiment Videos

  • Rats, guinea pigs, whales, rabbits, dogs, and pigs possess a single, C4B-like C4 specificity.
  • Sheep and cattle show two C4 types, one C4B-like and one C4A-like.

    • Conclusions:

    • The findings indicate the presence of multiple C4 loci in some species.
    • C4 locus duplication is either an ancient event predating mammalian divergence or resulted from multiple independent duplications.