Related Experiment Video
Updated: May 18, 2026
06:07
Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System
Published on: October 22, 2020
Clinical phenotypes related to smoking cessation
Markos Minas1, Eleni Apostolidou, Irene Goudouva
1Respiratory Medicine Department, University of Thessaly Medical School, Larissa, Biopolis 41110, Greece.
Journal of Substance Abuse Treatment
|October 2, 2012
Summary
Identifying distinct patient phenotypes at smoking cessation clinics reveals varying success rates. Tailoring interventions based on these phenotypes may improve quitting outcomes for diverse smoker profiles.
Area of Science:
- Clinical Medicine
- Addiction Psychiatry
- Public Health
Background:
- Specialized smoking cessation centers treat diverse patient populations.
- Understanding patient heterogeneity is crucial for optimizing cessation strategies.
Purpose of the Study:
- To identify distinct clinical phenotypes among patients attending a specialized smoking cessation center.
- To determine the smoking cessation rate for each identified phenotype one year post-evaluation.
Main Methods:
- A cohort of 783 smokers attending an outpatient clinic was analyzed.
- Data collected included demographics, smoking habits, tobacco dependence, and comorbidities.
- Smoking cessation rates and carbon monoxide levels were assessed at 1-year follow-up.
Main Results:
- The overall 1-year smoking cessation rate was 32.3%.
- Four distinct phenotypes were identified: young women (allergic profile, low dependence), men on varenicline (high dependence), men on bupropion SR (high dependence), and older men (high dependence, comorbidities).
- Cessation rates varied by phenotype: 33.8%, 39.4%, 23.3%, and 24.6%, respectively.
Conclusions:
- Patients in smoking cessation centers exhibit distinct clinical phenotypes.
- Phenotyping can facilitate a more personalized and effective approach to smoking cessation interventions.
Related Concept Videos
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
01:20COPD: Pathogenesis and Clinical Features
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
01:24Chronic Obstructive Pulmonary Disease
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
01:19Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations
Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
01:23Chronic Obstructive Pulmonary Disease II: Emphysema
Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.