Related Experiment Video

Updated: May 18, 2026

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
07:01

A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)

Published on: February 7, 2025

CKiD (CKD in children) prospective cohort study: a review of current findings

Cynthia J Wong1, Marva Moxey-Mims, Judith Jerry-Fluker

  • 1Department of Pediatrics, Division of Nephrology, Lucile Packard Children's Hospital, Palo Alto, CA, USA. wongcy8@stanford.edu

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|October 2, 2012
PubMed

Insights

Chronic kidney disease (CKD) in children is rising, impacting growth and neurocognition. Early intervention is crucial for better long-term health outcomes in pediatric CKD patients.

Area of Science:

  • Pediatric Nephrology
  • Chronic Disease Epidemiology

Background:

  • Chronic kidney disease (CKD) is a progressive condition with increasing global incidence in children.
  • CKD in pediatric populations leads to significant morbidity, including cardiovascular disease and cognitive impairment, mirroring adult complications.

Observation:

  • The Chronic Kidney Disease in Children (CKiD) Study is a prospective cohort of 586 children (ages 1-16) with CKD.
  • CKiD research has identified key risk factors for CKD progression and associated cardiovascular disease in children.
  • The study highlights CKD's unique impact on pediatric neurocognitive development and growth.

Findings:

  • CKD complications in children are diverse, affecting multiple organ systems and developmental trajectories.
  • Cardiovascular disease and neurocognitive deficits are highly prevalent comorbidities in children with CKD.
  • Risk factors for CKD progression and cardiovascular disease have been identified in the pediatric cohort.

Implications:

  • Initiating therapeutic interventions at an early age is essential for mitigating long-term morbidity and mortality in children with CKD.
  • Further research is needed to fully understand and address the spectrum of CKD-associated complications in children.
  • Early management strategies are critical for improving overall health outcomes and quality of life for pediatric CKD patients.

More Related Videos

Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease12:47

Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease

Published on: February 3, 2012

Assessment of Child Anthropometry in a Large Epidemiologic Study09:36

Assessment of Child Anthropometry in a Large Epidemiologic Study

Published on: February 2, 2017

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Longitudinal Research02:20

Longitudinal Research

Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
Observational Studies01:11

Observational Studies

Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One example of...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...