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Updated: May 18, 2026

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Published on: November 28, 2018
ATP-dependent intercellular Ca2+ signaling in the developing cochlea: facts, fantasies and perspectives
1Dipartimento di Fisica e Astronomia G. Galilei, Università di Padova, 35131 Padova, Italy. fabio.mammano@unipd.it
Abstract:
Hearing relies on a sensitive mechanoelectrical transduction process in the cochlea of the inner ear. The cochlea contains sensory, secretory, neural, supporting and epithelial cells which are all essential to the sound transduction process. It is well known that a complex extracellular purinergic signaling system contributes to cochlear homeostasis, altering cochlear sensitivity and neural output via ATP-gated ion channels (P2X receptors) and G protein-coupled P2Y receptors. This review focuses on the emerging roles of ATP that are currently under investigation in the developing sensory epithelium, with particular emphasis on the link between ATP release, Ca(2+) signaling, the expression and function of gap junction proteins connexin26 and connexin30, and the acquisition of hearing.
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