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Subclinical renal dysfunction in rheumatoid arthritis.

M Boers1, B A Dijkmans, F C Breedveld

  • 1Department of Rheumatology, University Hospital, Leiden, The Netherlands.

Arthritis and Rheumatism
|January 1, 1990
PubMed
Summary

Subclinical renal dysfunction is common in patients with chronic, seropositive rheumatoid arthritis (RA). Vasculitis and hypergammaglobulinemia were not identified as risk factors for this kidney dysfunction in the studied RA patients.

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Area of Science:

  • Nephrology
  • Rheumatology
  • Immunology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease.
  • RA can affect various organ systems, including the kidneys.
  • Subclinical renal impairment may be prevalent in RA patients.

Purpose of the Study:

  • To investigate the prevalence and nature of renal dysfunction in patients with chronic, seropositive RA.
  • To assess the association of vasculitis and hypergammaglobulinemia with renal dysfunction in RA.

Main Methods:

  • Studied renal function in 35 patients with chronic, seropositive RA.
  • Assessed glomerular filtration rate, proteinuria, urine concentration, and urinary tubular enzyme levels.
  • Categorized patients based on the presence of vasculitis and hypergammaglobulinemia.

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Main Results:

  • A significant proportion of RA patients exhibited subclinical renal dysfunction.
  • Decreased glomerular filtration rate observed in 8 patients.
  • (Micro)proteinuria in 11 patients, defective urine concentration in 10, and elevated urinary tubular enzymes in 15.
  • Vasculitis and hypergammaglobulinemia were not found to be significant risk factors for renal dysfunction in this cohort.

Conclusions:

  • Subclinical renal dysfunction is a common finding in patients with chronic, seropositive RA.
  • The presence of vasculitis or hypergammaglobulinemia did not correlate with increased risk of renal dysfunction in the studied RA population.
  • Further research is warranted to elucidate the mechanisms and long-term implications of renal involvement in RA.