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Related Experiment Videos

Enalapril induced angioedema.

M E Gianos1, W B Klaustermeyer, M Kurohara

  • 1Allergy and Immunology Section, Wadsworth VA Medical Center, Los Angeles, CA 90073.

The American Journal of Emergency Medicine
|March 1, 1990
PubMed
Summary
This summary is machine-generated.

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Angiodema, a serious swelling condition, can occur when taking enalapril, an ACE inhibitor. This reaction may happen soon after starting the medication or after long-term use, impacting the airway and face.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Adverse Drug Reactions

Background:

  • Angiodema is a potentially life-threatening adverse drug reaction.
  • Enalapril is an angiotensin-converting enzyme (ACE) inhibitor commonly prescribed for hypertension and heart failure.

Observation:

  • Three distinct cases of angiodema in patients treated with enalapril are reported.
  • Onset of angiodema varied from within hours of the first dose to after one year of continuous therapy.
  • Symptoms ranged from facial swelling to severe laryngeal and glottic edema requiring emergency intervention.

Findings:

  • Angiodema associated with enalapril can manifest at any point during treatment, both early and late.
  • Severe cases may necessitate emergency airway management, such as tracheostomy.

Related Experiment Videos

  • The mechanism may involve bradykinin potentiation and subsequent kinin system activation.

    • Implications:

    • Clinicians should maintain a high index of suspicion for enalapril-induced angiodema.
    • Awareness of the variable timing of onset is crucial for timely diagnosis and management.
    • Understanding the potential mechanism can inform preventative strategies and alternative treatment choices.