The use of transcranial Doppler pulsatility index to guide hyperosmolar therapy
Hosam M Al-Jehani1, Judith Marcoux, Mark R Angle
1Neurocritical Care Unit, Montreal Neurological Institute/Hospital, McGill University, Canada. hosam.aljehani@gmail.com
Insights
Transcranial Doppler (TCD) pulsatility index (PI) can guide hyperosmolar therapy for intracranial hypertension (ICP) when invasive monitoring is risky. Combining PI with optic nerve assessment refines ICP management.
Area of Science:
- Neurocritical care
- Neurology
- Medical technology
Background:
- Intracranial hypertension (ICH) management is crucial in neurocritical care.
- Guidelines for intracranial pressure (ICP) monitoring are lacking outside of traumatic brain injury.
- ICP monitoring involves invasive procedures with risks, especially in coagulopathy.
Observation:
- Transcranial Doppler (TCD) pulsatility index (PI) is an emerging surrogate marker for ICP.
- This technical report details using TCD PI to manage high ICP.
- PI guides optimal dosing of hyperosmolar agents.
Findings:
- TCD PI serves as a valuable adjunct for managing elevated ICP.
- It aids in guiding hyperosmolar therapy across various conditions causing ICH.
- Combining PI with optic nerve diameter evaluation minimizes confounding factors.
Implications:
- Non-invasive TCD PI offers a safer alternative for ICP monitoring.
- This method can improve the precision of hyperosmolar therapy.
- Enhanced ICP management strategies can lead to better patient outcomes.
Abstract:
Management of intracranial hypertension is a major cornerstone of neurocritical care. Apart from traumatic brain injury, there are no clear guidelines for intracranial pressure (ICP) monitoring. The insertion of ICP monitors is an invasive procedure with inherent risks and could be contraindicated in case of severe coagulopathy. The transcranial Doppler (TCD) pulsatility index (PI) has emerged as a surrogate marker for ICP. This is a technical report with illustrative cases on the use of PI in the management of high ICP, as a guide for optimal dosing of hyperosmolar agents we use in our institution. The use of TCD PI is a useful adjunct to guide the use of hyperosmolar therapy in various conditions with raised intracranial hypertension. We will discuss the combination of the PI determination with an anatomical evaluation of the optic nerve diameter to eliminate confounding factors in PI determination.
Related Concept Videos
Hyperosmolar Hyperglycemic State
Assessing Blood pressure using a doppler ultrasound
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:


