[An unusual case of transient ST-segment elevation during hypertensive crisis in a patient with left ventricular

Alberto Cappelletti1, Silvia Maggio, Francesco Maranta

  • 1Dipartimento Cardio-Toraco-Vascolare, Università Vita-Salute e Istituto Scientifico IRCSS San Raffaele, Milano, Italy. cappelletti.alberto@hsr.it

Giornale Italiano Di Cardiologia (2006)
|October 2, 2012
PubMed

Insights

Severe left ventricular hypertrophy can cause ST-segment elevation mimicking heart attack during high blood pressure. Prompt blood pressure reduction resolved these electrocardiogram changes, revealing no coronary artery blockage.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Medical Diagnostics

Background:

  • Left ventricular hypertrophy (LVH) is a common cardiac condition often associated with hypertension.
  • ST-segment elevation on electrocardiogram (ECG) typically indicates acute myocardial infarction (heart attack).
  • Hypertensive crises present significant challenges in differentiating cardiac emergencies.

Observation:

  • A 73-year-old patient with known severe LVH experienced acute ECG changes suggestive of myocardial infarction.
  • These changes occurred during a hypertensive crisis, with significantly elevated blood pressure.
  • Emergency coronary angiography was performed to rule out acute coronary syndrome.

Findings:

  • Coronary angiography revealed no evidence of coronary artery thrombosis (blood clot) or vasospasm (sudden narrowing).
  • The patient's ECG abnormalities progressively resolved as blood pressure was successfully lowered.
  • This suggests the ECG changes were a transient phenomenon related to the hypertensive state.

Implications:

  • The findings highlight that ST-segment elevation in hypertensive crisis with LVH may not always indicate acute myocardial infarction.
  • This case underscores the importance of considering non-ischemic causes for ST-segment elevation in the context of severe hypertension.
  • Accurate diagnosis and management of hypertensive emergencies are crucial to avoid unnecessary invasive procedures and guide appropriate treatment.

Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...