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High osteoporotic fracture risk and CVD risk co-exist in postmenopausal women

Joanna Makovey1, Monique Macara, Jian Sheng Chen

  • 1Institute of Bone and Joint Research, Kolling Institute, Royal North Shore Hospital, University of Sydney, Sydney, Australia. jmakovey@med.usyd.edu.au

Bone
|October 2, 2012
PubMed

Insights

This study found that higher fracture risk in women is linked to increased cardiovascular disease risk. Integrated risk assessment using algorithms like FRAX and Framingham can identify individuals needing intervention.

Area of Science:

  • Gerontology
  • Cardiology
  • Endocrinology

Background:

  • Previous studies linked osteoporosis risk factors, like bone mineral density (BMD), to cardiovascular outcomes.
  • However, integrated risk assessment using algorithms was not previously studied.

Purpose of the Study:

  • To investigate the association between fracture risk and cardiovascular disease (CVD) risk in peri- and postmenopausal women using established risk algorithms.

Main Methods:

  • 358 women (mean age 59.3) underwent BMD measurements.
  • Fracture risk was assessed using the WHO FRAX algorithm.
  • Cardiovascular disease risk was evaluated using the Framingham Risk Tool.

Main Results:

  • Women with higher 10-year major osteoporotic fracture risk had significantly higher cardiovascular risk (8.36% vs 4.634%).
  • Five-year CVD risk was significantly associated with 10-year major osteoporotic and hip fracture risk.
  • Highest CVD risk was linked to a 5.4-fold increased likelihood of higher major osteoporotic fracture risk.

Conclusions:

  • Fracture risk, assessed by FRAX, positively correlates with cardiovascular risk, assessed by Framingham.
  • Awareness of these concurrent risks is crucial for implementing targeted risk reduction strategies.
Abstract

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