Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Bone Markings01:26

Bone Markings

Bones have various surface features that help form joints and attach to other soft tissues. Depending on the function, bone markings are categorized into articulating projections, processes for attachment, depressions, and openings.
Articulating Projections
Articulating projections are found where two bones meet to form a joint. These structures are usually found at the ends of bones. The largest articulation is a rounded projection called the head, supported by a narrow neck at the ends of...
Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Bleeding in Fresh Concrete01:22

Bleeding in Fresh Concrete

Bleeding in fresh concrete occurs when water from the mix rises to the surface. This happens because the mix's solid components fail to retain all the water as they settle, leading to separation where water collects at the top. The severity of bleeding can be measured by assessing the total settlement or by noting the decrease in height per unit height of concrete.
Bleeding can cause several issues in the concrete structure. Sometimes, the rising water gets trapped beneath large aggregate...
Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

Cardiovascular System Abnormal Findings I: Inspection and Palpation

In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Faecal microbiota transplantation for patients with irritable bowel syndrome: abridged secondary publication.

Hong Kong medical journal = Xianggang yi xue za zhi·2024
Same author

Pyrroloquinoline quinone nutritional status alters lysine metabolism and modulates mitochondrial DNA content in the mouse and rat.

Biochimica et biophysica acta·2006
Same author

Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues.

The Journal of clinical endocrinology and metabolism·2004
Same author

Small bowel perforation after radiotherapy for cervical carcinoma.

Hong Kong medical journal = Xianggang yi xue za zhi·2003
Same author

Positively charged residues at positions 12, 17, and 18 of glucagon ensure maximum biological potency.

The Journal of biological chemistry·1998
Same author

Adrenocorticotropic hormone-secreting pheochromocytomas: the exception to the rule.

Surgery·1995
Same journal

Assessment of exclusive breastfeeding practices in a tribal district of Maharashtra: A cross-sectional study.

Journal of postgraduate medicine·2026
Same journal

Leveraging immersive technology with virtual emulation for training of nonmedico combatants: A randomized controlled trial.

Journal of postgraduate medicine·2026
Same journal

From clinic to microscope: A study of clinicopathological concordance in 5000 skin biopsies from a tertiary care center.

Journal of postgraduate medicine·2026
Same journal

Early anticoagulation with warfarin for pulmonary embolism complicating active gastric ulcer: A case against guideline-mandated delay.

Journal of postgraduate medicine·2026
Same journal

Paradoxical Hemophagocytic Lymphohistiocytosis to Stevens-Johnson Syndrome - Toxic Epidermal Necrolysis- A rare immune phenomenon.

Journal of postgraduate medicine·2026
Same journal

Anesthetic management of neonate with hypoplastic left heart syndrome posted for exploratory laparotomy.

Journal of postgraduate medicine·2026
See all related articles

Related Experiment Video

Updated: May 18, 2026

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
02:49

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

Published on: February 23, 2024

Mysterious bruises.

H Chen1, J Jiao, C P Cheung

  • 1Department of Medicine, Kingsbrook Jewish Medical Center, Brooklyn, NY, USA.

Journal of Postgraduate Medicine
|October 2, 2012
PubMed
Summary
This summary is machine-generated.

This case study details a 69-year-old man with acquired hemophilia A and pernicious anemia. Treatment with steroids and rituximab successfully eradicated the factor VIII inhibitor.

More Related Videos

Swine Model of Biofilm Infection and Invisible Wounds
07:16

Swine Model of Biofilm Infection and Invisible Wounds

Published on: June 16, 2023

Related Experiment Videos

Last Updated: May 18, 2026

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
02:49

A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds

Published on: February 23, 2024

Swine Model of Biofilm Infection and Invisible Wounds
07:16

Swine Model of Biofilm Infection and Invisible Wounds

Published on: June 16, 2023

Area of Science:

  • Hematology
  • Immunology

Background:

  • Acquired hemophilia A (AHA) is a rare bleeding disorder caused by autoantibodies against factor VIII.
  • It can present with spontaneous, severe bleeding and requires prompt diagnosis and management.

Observation:

  • A 69-year-old male presented with spontaneous bruising and hematomas.
  • Initial labs showed prolonged activated partial thromboplastin time (aPTT) with normal platelet count and international normalized ratio.
  • Factor VIII inhibitor was detected, confirming AHA.

Findings:

  • The patient also had pernicious anemia, an autoimmune condition.
  • Initial treatment with steroids normalized aPTT and undetectable factor VIII inhibitor levels.
  • A relapse occurred, necessitating treatment with recombinant factor VIIa, steroids, and rituximab.

Implications:

  • This case highlights the importance of a thorough workup for bleeding disorders, including the investigation of associated autoimmune conditions.
  • Combined immunosuppressive therapy (steroids and rituximab) can be effective in eradicating factor VIII inhibitors in AHA.
  • Early recognition and multidisciplinary management are crucial for favorable outcomes in acquired hemophilia A.