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Updated: May 18, 2026

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles
Published on: October 18, 2024
[TDP-43 proteinopathies - from frontotemporal lobar degeneration to inclusion body myositis]
Biruta Kierdaszuk1, Mariusz Berdyński, Cezary Zekanowski
1Katedra i Klinika Neurologii, Warszawski Uniwersytet Medyczny, Warszawa. bkierdaszuk@gmail.com
Abstract:
TDP-43, a newly described neurodegenerative protein, is of great interest to both neurologists and geneticists. At the beginning, its dysfunction was recognized in sporadic amyotrophic lateral sclerosis, frontotemporal lobar degeneration with ubiquitinated inclusions and in mixed forms. However, it was also proved that TDP-43 inclusions are in addition present in many other diseases, for example in inclusion body myositis. Furthermore, many genes and different loci may be involved in pathological TDP-43 accumulation in cells and tissues. Mutations in the TARDPB gene, progranulin gene (PGRNVCP) as well as a gene on chromosome 9p were found. The present paper is a summary on possible involvement of TDP-43 in various neurodegenerative disorders.
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