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Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
Published on: June 24, 2018
[Lack of phosphorus intake and nutrition]
Eiji Takeda1, Syoko Ikeda, Otoki Nakahashi
1Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Japan.
Abstract:
Since one gram of protein in food provides approximately 15 mg of phosphorus, phosphorus deficiency frequently observed in patients with protein-energy malnutrition (PEM). Chronic phosphorus deficiency in humans causes proximal myopathy. Acute hypophosphatemia may precipitate rhabdomyolysis. Plasma low phosphorus concentration suppresses erythrocyte synthesis and stores of 2,3-diphosphoglycerate (2,3-DPG) , which plays an important role in the affinity of hemoglobin for oxygen. Symptoms of nervous system dysfunction, such as weakness, apathy, a bedridden state, and intention tremors, are also observed in severe hypophosphatemia. Refeeding syndrome is caused by rapid refeeding in PEM, characterized by hypophosphatemia and has metabolic and clinical complications. This is potentially fatal, yet is preventable. Awareness and identification of at-risk patients is crucial to improving management.
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