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Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats

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Published on: March 11, 2016

Selenium and kidney disease.

Pedro Iglesias¹, Rafael Selgas, Sara Romero

¹Department of Endocrinology, Hospital Ramón y Cajal, Madrid, Spain. piglo65@gmail.com

Journal of Nephrology

|October 2, 2012

Summary

Selenium deficiency is common in kidney disease patients and may worsen health outcomes. Supplementation shows promise in improving immune function and reducing oxidative stress in these individuals.

Area of Science:

Biochemistry
Clinical Nutrition
Nephrology

Background:

Selenium (Se) is a vital trace element acting as a cofactor for selenoproteins involved in thyroid hormone metabolism, antioxidant defense, and immune function.
Se deficiency is linked to cardiovascular disease, infections, mortality, and is frequently observed in patients with acute kidney injury (AKI) and chronic kidney disease (CKD).
Hyposelenemia (low serum Se) and renal insufficiency are associated with increased risks of coronary heart disease mortality and all-cause mortality.

Purpose of the Study:

To evaluate the clinical consequences of hyposelenemia in patients with kidney disease.
To explore the relationship between low selenium levels and comorbidities associated with renal disease.
To investigate the potential benefits of selenium supplementation in renal patients.

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Main Methods:

Review of existing literature on selenium status in kidney disease.
Analysis of studies reporting on selenium levels, comorbidities, and mortality in renal patients.
Examination of data on the effects of selenium supplementation on immune function and oxidative stress markers.

Main Results:

Low serum Se levels are common in patients with AKI and CKD.
Hyposelenemia may contribute to immune dysfunction and increase mortality risk, particularly from infectious diseases in hemodialysis patients.
Selenium supplementation has shown potential to improve Se status, immune function, and reduce oxidative stress in renal patients.

Conclusions:

Intriguing links exist between selenium physiology and derangements in acute and chronic kidney disease.
Further research is needed to fully understand the clinical impact of hyposelenemia in kidney disease patients.
Available data suggest selenium supplementation may be beneficial, warranting further investigation into its necessity and efficacy.