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Cherry consumption and decreased risk of recurrent gout attacks

Yuqing Zhang1, Tuhina Neogi, Clara Chen

  • 1Boston University, Boston, MA 02118, USA. yuqing@bu.edu

Arthritis and Rheumatism
|October 2, 2012
PubMed

Insights

Consuming cherries, including cherry extract, significantly lowers the risk of recurrent gout attacks. This natural intervention shows promise for managing gout symptoms and reducing flare-ups.

Area of Science:

  • Rheumatology
  • Nutritional Science
  • Epidemiology

Background:

  • Gout is a common form of inflammatory arthritis characterized by recurrent attacks of severe joint pain.
  • Dietary factors are known to influence gout attacks, but specific food recommendations remain an area of active research.

Purpose of the Study:

  • To investigate the association between cherry intake and the risk of recurrent gout attacks in individuals diagnosed with gout.
  • To evaluate the impact of both whole cherry consumption and cherry extract supplementation on gout attack frequency.

Main Methods:

  • A case-crossover study design was employed, prospectively following 633 individuals with gout for one year.
  • Participants reported gout attacks and potential risk factor exposures, including cherry intake, over 2-day periods before attacks and control periods.
  • Conditional logistic regression analysis was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for gout attacks associated with cherry consumption.

Main Results:

  • Cherry intake over a 2-day period was linked to a 35% reduced risk of gout attacks (OR 0.65; 95% CI 0.50-0.85).
  • Cherry extract intake demonstrated a similar inverse association, with a 45% lower risk (OR 0.55; 95% CI 0.30-0.98).
  • The protective effect of cherries was consistent across various subgroups and was significantly enhanced when combined with allopurinol, reducing gout attack risk by 75% (OR 0.25; 95% CI 0.15-0.42).

Conclusions:

  • Cherry intake, in both whole fruit and extract forms, is associated with a significantly lower risk of recurrent gout attacks.
  • These findings support the inclusion of cherries as a dietary strategy for managing gout.
  • Further research may explore the specific bioactive compounds in cherries responsible for these anti-gout effects.
Abstract

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